IgA nephropathy

IgA nephropathy (IgA nephropathy, IgAN), is also called Berger's disease, is primary glomerular disease, glomerular mesangial IgA or IgA deposition mainly, with or without other deposition of immunoglobulins in the glomerular mesangium. The clinical performance is: Repeated episodes of macroscopic hematuria or microhematuria, may have varying degrees of proteinuria, some patients appear severe hypertension or renal failure.

The reason for having this disease

The pathogenesis of this disease has not been fully elucidated, it is possible to have relaxation with production and abnormal IgA clearance.

1.50% of the patients had their serum IgA levels increased, some patients looked like the immune complexes of circulating IgA in the blood.

2. Because toxin, bacteria and food proteins stimulate respiratory or gastrointestinal, mucosal IgA synthesis increased, IgA or immune complexes include IgA are deposited in the mesangial area, and activate the complement alternative approach, causing the Glomerular damage.

3. The same family member or HLA fellow countryman, it seems the multiple phenomenon of IgA nephropathy, explain that genetic factors play an important role.

In fact, proteinuria caused by IgA nephropathy is not as serious as that caused by many other problems associated with the kidneys. However, many patients in IgA nephropathy have proteinuria. Online doctor can help you at any time!
Clinical trials for 74 patients with IgA nephropathy was made and clinico-pathological data show that "renal survival" in the top five after the presentation was 100% in patients with consistently moderate proteinuria, 87% of those whose protein excretion reached in the moderate range, 69% with heavy proteinuria and nephrotic range was developed. From this test, we learn that proteinuria always indicates a poor prognosis for patients with IgA nephropathy, and in general, the more protein in the urine, the worse the prognosis.