What influence the prognosis of children with iga nephropathy?

Primary IgA nephropathy (inflammation) is the name of the immune pathological diagnosis, it repeated episodes of gross hematuria or microscopic hematuria, proteinuria may be associated with varying degrees of renal tissue to the main immunoglobulin IgA deposition characteristics. The influencing factors for prognosis of IgA Nephropathy in children mainly include:
Sex and onset age
It is uncertain about the influence of sex and age on the prognosis of IgA nephropathy in children. If it occurs at very young age, it can indicate low survival rate of kidneys. However, if it occurs at a higher age, the disease progresses very slowly.
Genetic factor
Genetic factor plays a vital role in influencing the prognosis of membranous nephropathy. If there is a family history of IgA nephropathy, the incidence of renal failure is comparatively high.
Hematuria
The prognosis of IgA nephropathy is associated with hematuria. Gross hematuria indicates a better prognosis than those with microscopic hematuria and proteinuria. This because parents usually attach more importance to episodic gross hematuria and take very early intervention treatment.
Proteinuria
Generally speaking, if persistent proteinuria is above 1g/d, it is a dangerous risk factor for prognosis of IgA nephropathy in children. If heavy proteinuria(500mg~3g) lasts for more than 6 months, it can worsen the prognosis of IgA nephropathy significantly.
High blood pressure
High blood pressure plays a vital role in affecting the prognosis of IgA nephropathy. The risk of developing renal insufficiency in among children with high blood pressure is 2.8 times than those without high blood pressure.
Renal insufficiency
Renal insufficiency in IgA nephropathy indicates a poor prognosis. Additionally, decreased GFR and the necrotic degree of renal tubule also can influence its prognosis.
Treatment
Treatment is a controllable and important factor in influencing the prognosis of IgA nephropathy in children. Proper treatment can stop the the disease progression and make children live a normal life like other healthy children.
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