Three main cause of evoked IgA

IgA is an immunoglobulin, an antibody is of human. Under unusual circumstances, in the kidney inflammation stimulated by a variety of factors such as lower, resulting in excessive deposition of IgA in the kidney glomerular mesangial area and other parts, together with antigens to form immune complexes, the structure of pathological cause kidney damage, caused by a series of clinical symptoms, known as IgA nephropathy. The clinical manifestations of recurrent gross hematuria or microscopic hematuria may be associated with varying degrees of proteinuria, can occur in some patients with severe hypertension or renal insufficiency. IgA nephritis induced for many reasons, here are three main reasons.
1 infection: This is a major cause of the disease, the infection is mentioned here include viral and bacterial infections. The most common were upper respiratory tract infections, urinary tract infections, skin infections, in everyday life, we should be more to avoid infection, avoid iga nephropathy.
2 immunity disorders: There are many causes of the disease, immune disorders is one of the most common reason. Serum can be detected in some patients at the pathogenic rheumatoid factor, explaining mucosal immunoglobulin sources, in addition to discover iga type-specific helper T cells increased in the peripheral blood lymphocytes of patients, suggesting the occurrence of iga nephropathy associated with abnormal immunity.
3 Genetic: Apart from the above two reasons, there is an often overlooked reason is genetic people. This conclusion is based on the Institute, the disease has a high incidence areas, and the higher incidence of genetic research and genetic study confirmed the occurrence of human disease have a certain relationship in some familial history of disease in the blood.